Multilineage Priming of Enhancer Repertoires Precedes Commitment to the B and Myeloid Cell Lineages in Hematopoietic Progenitors
作者： Elinore M. Mercer , Yin C. Lin , Christopher Benner , Suchit Jhunjhunwala , Janusz Dutkowski
DOI: 10.1016/J.IMMUNI.2011.06.013
关键词: Progenitor cell 、 Cellular differentiation 、 TCF3 、 Enhancer 、 Priming (immunology) 、 Cell biology 、 Immunology 、 Biology 、 B cell 、 Haematopoiesis 、 Myeloid
摘要: Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how are established maintained during developmental progression, we generated long-term cultures progenitors by enforcing the expression E-protein antagonist Id2. Hematopoietic that express Id2 multipotent readily differentiate upon withdrawal into committed B lineage cells, thus indicating a causative role for E2A (Tcf3) promoting fate. Genome-wide analyses revealed substantial fraction lymphoid myeloid enhancers premarked poised or active enhancer mark H3K4me1 progenitors. Thus, progenitors, multilineage priming elements precedes commitment
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