The effects of chronic phosphodiesterase-5 inhibitor use on different organ systems

摘要: Phosphodiesterase-5 (PDE-5) inhibitors selectively inhibit PDE-5 enzymes that are present in various tissues like penile tissue, platelets, vascular, and smooth muscle tissue. The drug's actions on these have lead to the successful therapeutic use patients suffering from conditions such as erectile dysfunction (ED) pulmonary hypertension. (PDE-5i) act tissue causing relaxation vasodilatation leading erection. In addition, particular when used conjunction with prostaglandin inhibitors, PDE-5i cause vasculature hence decreasing both arterial pressure resistance. also shown mildly decrease blood pressure, increase cardiac index, coronary flow experimental animals well human studies. Food Drug Administration (FDA) has approved three for treatment of ED: sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis) one hypertension: (Revatio). These agents highly selective compared other subclasses PDE almost identical pharmacological action but slightly different pharmacokinetics. Only little data exist about long-term their effects organ system. This paper reviews current information available chronic inhibitor use.