Estimation of cholesterol sulphate in blood plasma and in erythrocyte membranes from individuals with Down's syndrome or diabetes mellitus type I.
作者： M. Przybylska , M. Bryszewska , U. Nowicka , K. Szosland , J. Kȩdziora
DOI: 10.1016/0009-9120(95)00042-7
关键词: Diabetes mellitus 、 Internal medicine 、 Membrane 、 Chemistry 、 Chromatography 、 Diabetes mellitus type i 、 Densitometry 、 Cholesterol sulphate 、 S syndrome 、 Endocrinology 、 Blood plasma 、 Erythrocyte membrane
摘要: Abstract Objectives: Plasma and erythrocyte membrane cholesterol sulphate (CS) were measured in patients suffering from diabetes Down's syndrome. Design Methods: The procedure for separation determination of CS comprised HPTLC (high-performance thin-layer chromatography) densitometry. Results: mean plasma RBC membranes concentrations (±SD) the control group ( n = 16) was 188 ± 47 μg/dL 343 57 μg/10 12 RBC, respectively. In 15 with syndrome substantially higher levels found (diabetes: plasma-348 60 μg/dL; membranes-646 113 RBC; syndrome: plasma-245 54 427 74 RBC). Analysis variance multiple comparison (Newman-Keuls test) show statistically significant differences between all samples both erythrocytes, F (2,41) 52.24, p 34.92, Conclusions: It is postulated that may contribute to changes properties these pathological states.
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