Juvenile idiopathic arthritis and exposure to fine particulate air pollution.

摘要: Objectives Inhalation offine particulate matter, including particles with an aerodynamic diameter less than or equal to a 2.5-μm cut point (PM 2.5 ), has been associated systemic inflammation and the clinical presentation of various cardiopulmonary heath events. The urban area along Utah's Wasatch Mountains high PM concentrations during periods stagnant air conditions. Short-term inhalation exposures may trigger inflammatory events presenting as symptom onset in new patients juvenile idiopathic arthritis (JIA). This study evaluated potential associations between JIA temporal changes regional pollution measured by conditions concentrations. Methods A case-crossover design was used analyze ambient date 338 cases living on Front. Patients were drawn from Intermountain States Database Childhood Rheumatic Diseases (1993-2006). Time trends, seasonality, month, weekday controlled for matching. Selected exposure windows days model determine effect short term cumulative onset. Results Increased preceding 14 significantly elevated risk preschool aged children (RR=1.60, 95% CI 1.00―2.54) but not older children. Elevated larger males JIA. Conclusions Exposure polluted be environmental factor young children, potentially triggered pollution-induced pulmonary mediated inflammation.