Effects of spontaneously hypertensive rat plasma on blood pressure and tail artery calcium uptake in normotensive rats.

摘要: Previous studies have described the presence of humoral hypertensive factors in spontaneously rats (SHR). Other that increase calcium uptake vascular tissue. In this study, we attempted to confirm, and thereby correlate, both types SHR plasma. Intravenous infusion or bolus administration dialyzed plasma consistently induced an blood pressure normotensive rats. This response was somewhat delayed, with peak pressures occurring /sup 45/ minutes after 90 Spontaneously rat also increased 45/Ca isolated tail arteries a dose-dependent manner, time course similar for administration. These findings suggest, therefore, substance exists can intracellular tissues pressure.