Human immunodeficiency virus-neutralizing human antibodies with improved breadth and potency
作者： Mei-Yun Zhang , Dimiter S. Dimitrov
DOI:
关键词: Biology 、 Human immunodeficiency virus (HIV) 、 Glycoprotein 、 Potency 、 Epitope 、 Antibody 、 Immunology 、 Antigen binding 、 Nucleic acid 、 Fusion protein 、 Virology
摘要: The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope HIV recognized by is inducible, and binding enhanced presence CD4 co-receptor, related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions methods use inhibit infection a at risk becoming infected with reduce severity treat HIV.
lens.org参考文章(80)
Karl J. Guegler, Jennifer L. Hillman, Janice Au-Young, Neil C. Corley, Preeti Lal, Y. Tom Tang, Mariah R. Baughn, Henry Yue, Human immune system associated molecules ,(1998)
Peter D. Kwong, Wayne A. Hendrickson, Richard T. Wyatt, Joseph G. Sodroski, Glycosylated modified primate lentivirus envelope polypeptides ,(1998)
Carlo Rizzuto, Joseph Sodroski, Short Communication: Fine Definition of a Conserved CCR5-Binding Region on the Human Immunodeficiency Virus Type 1 Glycoprotein 120 AIDS Research and Human Retroviruses. ,vol. 16, pp. 741- 749 ,(2000) , 10.1089/088922200308747
Mei-Yun Zhang, Dimiter S. Dimitrov, Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries ,(2003)
Jonathan M. Gershoni, Antibodies directed against binding-associated epitopes ,(1993)
J P Moore, Q J Sattentau, H Yoshiyama, M Thali, M Charles, N Sullivan, S W Poon, M S Fung, F Traincard, M Pinkus, Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains. Journal of Virology. ,vol. 67, pp. 6136- 6151 ,(1993) , 10.1128/JVI.67.10.6136-6151.1993
Nai-Kong V. Cheung, Hong-Fen Guo, Method for preparation of single chain antibodies ,(2002)
Carl T. Wild, Carol D. Weiss, METHODS OF ELICITING BROADLY NEUTRALIZING ANTIBODIES TARGETING HIV-1 gp41 ,(2000)
Anthony Louis Devico, Ranajit Pal, Mangalasseril G. Sarngadharan, HIV immunogenic complexes ,(1994)
Sanjay K. Phogat, Dennis Burton, Xiadong Xiao, Yuuei Shu, Maxime Moulard, Mei-Yun Zhang, Dimiter S. Dimitrov, Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by env-cd4-co-receptor complexes ,(2002)