Concise Synthesis of Pyrrolidine and Indolizidine Alkaloids by a Highly Convergent Three‐Component Reaction
作者： Guillaume Lapointe , Kurt Schenk , Philippe Renaud
关键词: Reductive amination 、 Organic chemistry 、 Yield (chemistry) 、 Chemistry 、 Pyrrolidine 、 Monomorine I 、 Total synthesis 、 Indolizidine 、 Enantioselective synthesis 、 Radical 、 Stereochemistry
摘要: The synthesis of pyrrolidine and indolizidine derivatives through radical carboazidation alkenes with alpha-iodoketones, followed by reductive amination, is described. When properly substituted, further lactamization afforded pyrrolizidinones in good yield. This carboazidation/reductive amination sequence was efficiently applied to the total three different simple alkaloids, including (+/-)-monomorine I.
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