Antidepressant-like effects of long-term sarcosine treatment in rats with or without chronic unpredictable stress.

摘要: Sarcosine, an N-methyl-d-aspartate receptor enhancer, can improve depression-like behavior in rodent models and depression humans. We found that a single dose of sarcosine exerted antidepressant-like effects with rapid concomitant increases the mammalian target rapamycin (mTOR) signaling pathway activation enhancement α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPAR) membrane insertion. Sarcosine may play crucial role developing novel therapy for depression. For detailed understanding sarcosine, this study examined long-term treatment on forced swim test (FST), mTOR signaling, AMPAR insertion rats. The were naive rats exposed to chronic unpredictable stress (CUS). Long-term (560mg/kg/d 21 d) significantly ameliorated increased immobility induced by CUS FST, reaffirming potential as antidepressant depressed patients. same exhibited no such effect despite both groups. Our findings clearly show CUS-exposed are sensitive FST response at is absent Nevertheless, distinct sensitivity or without not associated activated Additionally, behavioral molecular basis responses vital important personalized programs increase probability success when treating