The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product
作者： Mathilde Lachia , Christopher J. Moody
DOI: 10.1039/B705663J
关键词: Indole test 、 Aminal 、 Combinatorial chemistry 、 Biology 、 Oxazole 、 Natural product 、 Organic chemistry
摘要: Covering: 1991 to August 2007 The complex structure of the marine metabolite diazonamide A comprises a dichlorinated indole bis-oxazole heteroaromatic fragment, and [b]-fused dihydrobenzofuran–dihydroindole unit containing an aminal carbon, all incorporated within strained double macrocyclic array. This review details synthetic studies on this fascinating natural product starting from early original (1991–2001), through synthesis originally proposed subsequent structural revision, eventual successful syntheses itself. Throughout we focus innovative ways in which chemists have approached challenges posed by product.
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