Outer-Sphere Direction in Iridium C-H Borylation
作者： Philipp C. Roosen , Venkata A. Kallepalli , Buddhadeb Chattopadhyay , Daniel A. Singleton , Robert E. Maleczka
DOI: 10.1021/JA303443M
关键词: Hydrogen bond 、 Borylation 、 Oxygen 、 Catalysis 、 Ligand 、 Outer sphere electron transfer 、 Proton 、 Medicinal chemistry 、 Chemistry 、 Photochemistry 、 Iridium
摘要: The NHBoc group affords ortho selective C–H borylations in arenes and alkenes. Experimental computational studies support an outer sphere mechanism where the N–H proton hydrogen bonds to a boryl ligand oxygen. regioselectivities are unique complement those of directed metalations.
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