Liquid pharmaceutical formulations for injection comprising thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole and uses thereof
作者： Alexander M. Klibanov , Alan Crane , Robert S. Langer , Kevin Love , Alisha K. Weight
DOI:
关键词: Imidazole 、 Thiamine pyrophosphate 、 Viscosity 、 Chemistry 、 Chromatography
摘要: Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such can be rapidly and conveniently administered by subcutaneous (SC) or intramuscular (IM) injection, rather than lengthy intravenous infusion. These include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, organophosphates. The viscosity the formulation is significantly reduced addition one more
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