Secreted Phospholipase A2s
作者： Eric Haas , David W. Stanley
DOI: 10.1016/B978-008055232-3.63681-5
关键词: Pancreatic juice 、 Pathophysiology 、 Biology 、 Biochemistry 、 Lipid signaling 、 Snake venom 、 Enzyme 、 Venom 、 Toxicity 、 Phospholipase
摘要: The family of secretory phospholipase A2 enzymes (sPLA2) were the first known A2s (PLA2s), and originally discovered over one hundred years ago in human pancreatic juice a snake venom. In early years, PLA2s fluids other mammals many venoms. It was thought predominant biological significance sPLA2 lay their digestive actions. Later work revealed that sPLA2s act large number physiological functions, including release lipid mediators, host defense, pathophysiology venom toxicity. Although it reasonable to suppose all these PLA2-mediated events followed from catalytic actions …
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