The effect of methimazole pretreatment on the efficacy of radioactive iodine therapy in Graves' hyperthyroidism: one-year follow-up of a prospective, randomized study.
作者： Vânia A. Andrade , Jorge L. Gross , Ana Luiza Maia
关键词: Clinical research 、 Clinical trial 、 Graves' disease 、 Prospective cohort study 、 Endocrinology 、 Medicine 、 Radiation therapy 、 Thyroid 、 Internal medicine 、 Antithyroid agent 、 Iodine
摘要: The effect of antithyroid drugs on the efficacy radioiodine (131I) treatment is still controversial. This study evaluated methimazole pretreatment 131I therapy in Graves’ hyperthyroidism. Sixty-one untreated patients were randomly assigned to receive alone (32 patients) or plus with (30 mg/d; 29 patients). was administered 4 d after drug discontinuation. calculated dose 200 μCi/g thyroid tissue as estimated by ultrasound, corrected 24-h uptake. Serum TSH, T4, and free T4 measured before therapy, day treatment, then monthly for 1 yr. Considering cure euthyroidism hypothyroidism, based measurement, approximately 80% from both groups cured 3 months beginning treatment. After yr similar terms persistent hyperthyroidism (15.6% vs. 13.8%), (28.1% 31.0%), hypothyroidism (56.3% 55.2%). Relaps...
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Anders Israelsson, Ingemar Dahlqvist, Lars-Erik Holm, Göran Lundell, Incidence of Hypothyroidism Occurring Long after Iodine-131 Therapy for Hyperthyroidism The Journal of Nuclear Medicine. ,vol. 23, pp. 103- 107 ,(1982)
Kenneth P. Offord, Alan J. Cunnien, Ian D. Hay, Colum A. Gorman, Paul W. Scanlon, Radioiodine-induced hypothyroidism in Graves' disease: factors associated. The Journal of Nuclear Medicine. ,vol. 23, pp. 978- 983 ,(1982)
Erik C.V. Holmberg, Gertrud E.B. Berg, Margareta Fink, Annika M.K. Michanek, Iodine-131 Treatment of Hyperthyroidism: Significance of Effective Half-life Measurements The Journal of Nuclear Medicine. ,vol. 37, pp. 228- 232 ,(1996)
H. PETERS, C. FISCHER, U. BOGNER, C. REINERS, H. SCHLEUSENER, Treatment of Graves' hyperthyroidism with radioiodine: results of a prospective randomized study. Thyroid. ,vol. 7, pp. 247- 251 ,(1997) , 10.1089/THY.1997.7.247
Henry B Burch, Barbara L Solomon, Leonard Wartofsky, Kenneth D Burman, Discontinuing Antithyroid Drug Therapy before Ablation with Radioiodine in Graves Disease Annals of Internal Medicine. ,vol. 121, pp. 553- 559 ,(1994) , 10.7326/0003-4819-121-8-199410150-00001
MargaretA. Flower, Amal Al-Saadi, CliveL. Harmer, V.Ralph McCready, RobertJ. Ott, Dose-response study on thyrotoxic patients undergoing positron emission tomography and radioiodine therapy. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 21, pp. 531- 536 ,(1994) , 10.1007/BF00173041
E. J. Wayne, Clinical and Metabolic Studies in Thyroid Disease—I BMJ. ,vol. 1, pp. 1- 11 ,(1960) , 10.1136/BMJ.1.5165.1
Osama Sabri, Michael Zimny, Gernot Schulz, Mathias Schreckenberger, Patrick Reinartz, Klaus Willmes, Udalrich Buell, None, Success rate of radioiodine therapy in Graves' disease: the influence of thyrostatic medication. The Journal of Clinical Endocrinology and Metabolism. ,vol. 84, pp. 1229- 1233 ,(1999) , 10.1210/JCEM.84.4.5588
ROBERT VOLPÉ, Evidence that the immunosuppressive effects of antithyroid drugs are mediated through actions on the thyroid cell, modulating thyrocyte-immunocyte signaling: a review. Thyroid. ,vol. 4, pp. 217- 223 ,(1994) , 10.1089/THY.1994.4.217
Vitaya Sridama, Maureen McCormick, Edwin L. Kaplan, Renee Fauchet, Leslie J. DeGroot, Long-Term Follow-up Study of Compensated Low-Dose 131I Therapy for Graves' Disease The New England Journal of Medicine. ,vol. 311, pp. 426- 432 ,(1984) , 10.1056/NEJM198408163110702