Antimalarial activities of 25 derivatives of artemisinine against chloroquine-resistant plasmodium berghei

摘要: The antimalarial activities of 25 derivatives artemisinine, including dihydroartemisinine, 13 ethers, 6 esters and 5 carbonates, were compared. Each compound, dissovlved in tea seed oil, was injected intramuscularly into mice infected with the chloroquine-resistant strain Plasmodium berghei. Adopting SD90 as a comparision criterion, results showed that many much more potent than artemisinine. They are SM224(O-methyl beta) SM241 (butyryl dihydroartmisinine, alpha) SM108 ( propionyl esters, SM242(propoxy carbonyl alpha), SM275( ethoxy alpha+beta), SM223 (ethoxy alpha ) SM 276 phenoxy alpha+beta) carbonates. Their chemical structures values presented Table 1.