Regulatory T Cells in Severe Persistent Asthma in the Era of Monoclonal Antibodies Target Therapies.

摘要: Asthma is an immunoinflammatory disease characterized by bronchial hyper-reactivity to different external stimuli. New monoclonal target treatments have been developed, but few studies investigated the role of regulatory T cells in severe asthma and modulatory effect biological therapy on cell functions. Their dysfunction may contribute development exacerbation asthma. Here we review recent literature potential immunological pathogenesis The analysis was performed terms functions their possible interactions with mechanisms action novel treatment for In era therapies asthma, little data available effects what could be a new therapy: antibody targeting numbers