Activity of the hypothalamic–pituitary–adrenal axis of prenatally stressed male rats in experimental model of depression
作者： N. E. Ordyan , S. G. Pivina , V. V. Rakitskaya , V. K. Akulova
DOI: 10.1134/S0022093016010063
关键词: Hypothalamus 、 Vasopressin 、 Endocrinology 、 Psychology 、 Corticosterone 、 Adrenocorticotropic hormone 、 Prenatal stress 、 Adrenal cortex 、 Hypothalamic–pituitary–adrenal axis 、 Corticotropin-releasing hormone 、 Internal medicine
摘要: Changes in activity of the hypothalamic–pituitary–adrenal (HPA) axis were examined adult, prenatally stressed male rats experimental depression model ‘learned helplessness’. It was shown that males descending from intact mothers a depressive-like state accompanied by an increase entire HPA axis. Namely, expression corticotropin-releasing hormone (CRH) hypothalamic paraventricular nucleus (PVN) increased coupled to rise plasma levels ACTH and corticosterone as well adrenal weight. At same time, born who suffered stress during last week pregnancy decrease detected both central (hypothalamus) peripheral (adrenal cortex) parts this regulatory hormonal axis, analogous we revealed previously ‘stress–restress’ model. is concluded prenatal modifies sensitivity animals inescapable intense impacts, manifested specific pattern after stressing.
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