Lubiprostone for the Treatment of Functional Constipation in Children
作者： Paul E. Hyman , Carlo Di Lorenzo , Laurel L. Prestridge , Nader N. Youssef , Ryuji Ueno
DOI: 10.1097/MPG.0000000000000176
关键词: Lubiprostone 、 Functional constipation 、 Multicenter study 、 Anesthesia 、 Internal medicine 、 Gastroenterology 、 Treatment outcome 、 Treatment options 、 Medicine 、 Defecation 、 Pediatrics, Perinatology, and Child Health
摘要: ABSTRACTObjectives:Pediatric functional constipation is common; effective, easily administered treatment options are limited. Lubiprostone an oral chloride channel protein-2 activator that stimulates gastrointestinal fluid secretion, softens stools, and facilitates bowel movements (BMs). We evalu
wkhealth.com参考文章(22)
William H Dery, Wendy S Biggs, Evaluation and treatment of constipation in infants and children. American Family Physician. ,vol. 73, pp. 469- 477 ,(2006)
J. F. JOHANSON, R. UENO, Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Alimentary Pharmacology & Therapeutics. ,vol. 25, pp. 1351- 1361 ,(2007) , 10.1111/J.1365-2036.2007.03320.X
Anthony J. Lembo, John F. Johanson, Henry P. Parkman, Satish S. Rao, Philip B. Miner, Ryuji Ueno, Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation. Digestive Diseases and Sciences. ,vol. 56, pp. 2639- 2645 ,(2011) , 10.1007/S10620-011-1801-0
Douglas Drossman, John F. Johanson, Ryuji Ueno, Charles F. Barish, Efficacy and safety of lubiprostone in patients with chronic constipation. Digestive Diseases and Sciences. ,vol. 55, pp. 1090- 1097 ,(2010) , 10.1007/S10620-009-1068-X
John F Johanson, Dan Morton, Joseph Geenen, Ryuji Ueno, Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. The American Journal of Gastroenterology. ,vol. 103, pp. 170- 177 ,(2008) , 10.1111/J.1572-0241.2007.01524.X
S. J. Lewis, K. W. Heaton, Stool Form Scale as a Useful Guide to Intestinal Transit Time Scandinavian Journal of Gastroenterology. ,vol. 32, pp. 920- 924 ,(1997) , 10.3109/00365529709011203
Brian E. Lacy, L. Campbell Levy, Lubiprostone : A chloride channel activator Journal of Clinical Gastroenterology. ,vol. 41, pp. 345- 351 ,(2007) , 10.1097/01.MCG.0000225665.68920.DF
Diane K. Wysowski, Ann Corken, Hugo Gallo-Torres, Lilia Talarico, Evelyn M. Rodriguez, Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions. The American Journal of Gastroenterology. ,vol. 96, pp. 1698- 1703 ,(2001) , 10.1111/J.1572-0241.2001.03927.X
Carlo Di Lorenzo, David Forbes, Ernesto Guiraldes, JS Hyams, Annamaria Staiano, LS Walker, Childhood Functional Gastrointestinal Disorders: Child/Adolescent Gastroenterology. ,vol. 130, pp. 1527- 1537 ,(2006) , 10.1053/J.GASTRO.2005.08.063
Lawrence R. Schiller, David A. Johnson, Balancing drug risk and benefit: toward refining the process of FDA decisions affecting patient care. The American Journal of Gastroenterology. ,vol. 103, pp. 815- 819 ,(2008) , 10.1111/J.1572-0241.2008.01818.X