Evaluation of Cysteine Metabolism in the Rat Liver and Kidney Following Intravenous Cocaine Administration and Abstinence
作者： Danuta Kowalczyk-Pachel , Małgorzata Iciek , Anna Bilska-Wilkosz , Magdalena Górny , Joanna Jastrzębska
关键词: Pharmacology 、 Kidney 、 Cysteine 、 Drug Abstinence 、 Self-administration 、 Metabolism 、 Reactive oxygen species 、 Chemistry 、 Abstinence 、 Cysteine metabolism
摘要: Many toxic effects of cocaine are attributed to reactive oxygen species (ROS) generated during its metabolism. Recently, it has been suggested that the biological action ROS is often confused with endogenously sulfur (RSS). The aim this study was evaluate impact on thiols and RSS in rat liver kidney drug self-administration (SA) paradigm yoked delivery model (YC) followed by abstinence extinction training. level as well formed anaerobic metabolism cysteine sulfate were assayed. In addition, activity enzymes involved formation glutathione determined. liver, following direct administration (SA YC), levels decreased, while kidneys, increased contents both groups. These changes maintained these tissues abstinence. sulfates changed only liver. kidney, shifted towards an pathway. Our demonstrates for first time thiol rats after
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