Stress-induced escalation of alcohol self-administration, anxiety-like behavior, and elevated amygdala Avp expression in a susceptible subpopulation of rats.

摘要: Comorbidity between alcohol use and anxiety disorders is associated with more severe symptoms poorer treatment outcomes than either of the conditions alone. There a well-known link stress development these disorders, post-traumatic disorder as prototypic example. Post-traumatic can arise consequence experiencing traumatic events firsthand also after witnessing them. Here, we used model social defeat witness in rats, to study shared mechanisms stress-induced anxiety-like behavior escalated self-administration. Similar what observed clinically, found considerable individual differences susceptibility resilience stress. Both among defeated subpopulation which exposure was followed by emergence increased escalation We then profiled gene expression tissue from amygdala, key brain region regulation stress, use, disorders. When comparing "comorbid" resilient socially identified strong upregulation vasopressin oxytocin, this correlated positively magnitude self-administration behavior. A similar trend comorbid rats. Together, our findings provide novel insights into molecular underpinning comorbidity