Recruitment and Immobilization of a Fluorinated Biomarker Across an Interfacial Phospholipid Film using a Fluorocarbon Gas
作者： Guang Yang , Miriam O'Duill , Véronique Gouverneur , Marie Pierre Krafft
关键词: Perfluorohexane 、 Monolayer 、 Drug delivery 、 Dipalmitoylphosphatidylcholine 、 Aqueous solution 、 Phospholipid 、 Organic chemistry 、 Fluorocarbon 、 Langmuir 、 Chemistry 、 Chemical engineering
摘要: Perfluorohexane gas when introduced in the air atmosphere above a film of phospholipid self-supported on an aqueous solution C2F5-labeled compounds causes recruitment and immobilization latter interfacial film. When forms liquid-condensed Gibbs monolayer, which is case for dipalmitoylphosphatidylcholine (DPPC), molecule remains trapped monolayer after removal F-hexane. Investigations involve bubble profile analysis tensiometry (Gibbs films), Langmuir monolayers microbubble experiments. The new phenomenon was utilized to incorporate hypoxia biomarker, nitrosoimidazole (EF5), shells. This finding opens perspectives delivery fluorinated therapeutic molecules biomarkers.
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