Na+ channels must deactivate to recover from inactivation.
作者： Chung-Chin Kuo , Bruce P. Bean
DOI: 10.1016/0896-6273(94)90335-2
关键词: Communication channel 、 Biophysics 、 Time constant 、 Hyperpolarization (biology) 、 Kinetics 、 Chemistry 、 Voltage dependence
摘要: Abstract We studied the kinetics of recovery from inactivation voltage-dependent Na + channels in rat hippocampal CA1 neurons. Recovery proceeded exponentially after an initial delay and was accompanied by a tiny ionic current. Both time constant became shorter with increasing hyperpolarization. Negative to −170 mV, rate saturated at ∼4 ms −1 (22°C). block anticonvulsant drug diphenylhydantoin far slower, but pattern voltage dependence very similar. Our results suggest that, analogous coupling between channel activation development inactivation, is coupled deactivation. Such ensures little "leak" current during highly voltage-sensitive repriming for next impulse.
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