Subclinical intestinal inflammation: an inherited abnormality in Crohn’s disease relatives?
作者： Bjarni Thjodleifsson , Gudmundur Sigthorsson , Nick Cariglia , Inga Reynisdottir , Daniel F. Gudbjartsson
DOI: 10.1016/S0016-5085(03)00383-4
关键词: Internal medicine 、 Immunology 、 Gastroenterology 、 Crohn's disease 、 Feces 、 Confidence interval 、 Risk factor 、 Subclinical infection 、 Disease 、 Calprotectin 、 Medicine 、 Immunopathology
摘要: Abstract Background & aims: One approach to unraveling the genetics of complex inherited disease, such as Crohn's is search for subclinical disease markers among unaffected family members. We assessed possible presence, prevalence, and inheritance pattern intestinal inflammation in apparently healthy relatives patients with disease. Methods: A total 49 16 spouses, 151 (58%) 260 available first-degree underwent a test (fecal calprotectin concentration). The mode was from 36 index (by variance component analysis) when more than 50% were studied. Results: Fecal concentrations (47 mg/L; confidence interval [CI], 27–95 mg/L) (11 CI, 9–14 differed significantly ( P > 0.5). concentration increased 49% all fecal had an that most consistent additive pattern. Conclusions: There high prevalence conforms best genetic basis this abnormality may represent risk factor
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