From Start to S Phase: Early Events in the Yeast Cell Cycle
作者： Michael Mendenhall
DOI: 10.1007/978-1-4612-2374-0_2
关键词: Cyclin Gene 、 Cell biology 、 Cyclin 、 Transcription (biology) 、 DNA repair 、 Kinase 、 DNA replication 、 Chemistry 、 Cyclin-dependent kinase 、 Signal transduction
摘要: The major events of eukaryotic cell division are coordinated by a highly conserved set genes that center on the cyclins and cyclin-dependent protein kinases (CDKs). Due to their central role in diverse processes include signal transduction, transcription, DNA replication, repair, apoptosis, differentiation, carcinogenesis (1), factors influencing activity CDKs have come under intense scrutiny since discovery. Not surprisingly, regulation is complex. levels cyclin activators determined periodic changes transcription rates (2) stability (3). Both stimulatory inhibitory phosphorylations CDK catalytic subunit control multiple phosphatases been described subcellular localization CDK/cyclin complexes also strict controls (4–7).
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