The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.
作者： Anja Henn , Søren Lund , Maj Hedtjärn , André Schrattenholz , Peter Pörzgen
关键词: Downregulation and upregulation 、 Biology 、 In vivo 、 Cell 、 Cell culture 、 Transcriptome 、 Neurodegeneration 、 Cell biology 、 Inflammation 、 Microglia 、 Immunology
摘要: … This comparison showed that BV-2 cells have an overall … Virtually all (90%) of those genes that were regulated in BV-2 … and BV-2 cells Primary murine microglia (PM) or BV-2 cells were …
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altex.ch 参考文章(58)
Anne de Brugerolle, SkinEthic Laboratories, a company devoted to develop and produce in vitro alternative methods to animal use. ALTEX-Alternatives to Animal Experimentation. ,vol. 24, pp. 167- 171 ,(2007) , 10.14573/ALTEX.2007.3.167
Fumiyuki Hattori, Shinzo Oikawa, Peroxiredoxins in the central nervous system. Sub-cellular biochemistry. ,vol. 44, pp. 357- 374 ,(2007) , 10.1007/978-1-4020-6051-9_17
Marcel Leist, Thomas Hartung, Pierluigi Nicotera, The dawning of a new age of toxicology. ALTEX-Alternatives to Animal Experimentation. ,vol. 25, pp. 103- 114 ,(2008) , 10.14573/ALTEX.2008.2.103
Silke Faehnrich, Wilhelm Gerhard Dirks, Isabelle Annick Janine Estella, Hans Guenter Drexler, Short tandem repeat DNA typing provides an international reference standard for authentication of human cell lines. ALTEX-Alternatives to Animal Experimentation. ,vol. 22, pp. 103- 109 ,(2005)
Marcel Leist, Suzanne Kadereit, Stefan Schildknecht, Food for Thought ... on the Real Success of 3R Approches ALTEX-Alternatives to Animal Experimentation. ,vol. 25, pp. 17- 24 ,(2008) , 10.14573/ALTEX.2008.1.17
Jeppe Falsig, Markus Latta, Marcel Leist, Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95‐driven apoptosis Journal of Neurochemistry. ,vol. 88, pp. 181- 193 ,(2003) , 10.1111/J.1471-4159.2004.02144.X
Søren Lund, Peter Porzgen, Anne Louise Mortensen, Henrik Hasseldam, Donna Bozyczko-Coyne, Siegfried Morath, Thomas Hartung, Marina Bianchi, Pietro Ghezzi, Malika Bsibsi, Sipke Dijkstra, Marcel Leist, Inhibition of microglial inflammation by the MLK inhibitor CEP-1347 Journal of Neurochemistry. ,vol. 92, pp. 1439- 1451 ,(2005) , 10.1111/J.1471-4159.2005.03014.X
Ryan J. Horvath, Nancy Nutile-McMenemy, Matthew S. Alkaitis, Joyce A. DeLeo, Differential migration, LPS-induced cytokine, chemokine and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures Journal of Neurochemistry. ,vol. 107, pp. 557- 569 ,(2008) , 10.1111/J.1471-4159.2008.05633.X
Bentham Science Publisher Sung Joong Lee, Bentham Science Publisher Soojin Lee, Toll-Like Receptors and Inflammation in the CNS Current Drug Targets - Inflammation & Allergy. ,vol. 1, pp. 181- 191 ,(2002) , 10.2174/1568010023344698
Elke Thedinga, In vitro system for the prediction of hepatotoxic effects in primary hepatocytes. ALTEX-Alternatives to Animal Experimentation. ,vol. 24, pp. 22- 34 ,(2007) , 10.14573/ALTEX.2007.1.22