[Effect of dimethyl sulfoxide on the extent of DNA single-strand breaks and alkali-labile sites induced by 365 nm UV-radiation in human blood lymphocyte nucleoids].

作者: Osipov An , Pustovalova Mv , Smetanina Nm

DOI:

关键词: DNAAlkali metalDNA damageNucleoidLymphocyteBiologyMolecular biologyDimethyl sulfoxideRadiationRadical

摘要: It is shown that exposure of 365 nm UV radiation at doses 10, 20 and 50 kJ/m2 induces a dose-dependent increase in DNA single-strand breaks alkali-labile sites (SSB ALS) detected by comet halo assays human blood lymphocyte nucleoids. Adding 10% dimethyl sulfoxide (DMSO) reduces the SSB ALS yields--in 3 times. A strong drop output UV-A-induced nucleoids presence DMSO shows leading role *OH radicals this damage formation under to 365-nm UV-radiation.

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