Expression of Topoisomerase 1 and carboxylesterase 2 correlates with irinotecan treatment response in metastatic colorectal cancer
作者： Chen Shaojun , Hua Li , Huang Haixin , Li Guisheng
DOI: 10.1080/15384047.2017.1414754
关键词: Medicine 、 Immunohistochemistry 、 Colorectal cancer 、 Oncology 、 Chemotherapy 、 Treatment response 、 Topoisomerase 、 Pathogenesis 、 Internal medicine 、 Irinotecan 、 Carboxylesterase
摘要: Topoisomerase 1 (TOPO-1) and carboxylesterase 2 (CES-2) are found to play crucial roles in the pathogenesis of various cancers. The prognostic role TOPO-1 CES-2 patients with metastatic colorectal cancer (mCRC) who underwent irinotecan chemotherapy was largely unknown. In current study, we assessed expression mCRC analyzed its potential relevance based therapy. A total 98 were included this study. tissues evaluated by immunohistochemistry. For TOPO-1, 46 showed high 52 low expression. CES-2, 53 45 correlation between or clinicopathological characteristics analyzed. Neither nor had significant age, gender, tumor site, grade sites patients. However, but not TOP-1 positively correlated better curative effect. Kaplan-Meier log-rank test applied assess progression-free survival (PFS)/overall (OS) High longer PFS OS. summary, our findings suggest that may important sensitivity Evaluation provide preliminary clinical evidence for management irinotecan-based therapy
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