Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals
作者： A. O. Speak , M. Salio , D. C. A. Neville , J. Fontaine , D. A. Priestman
关键词: CD1D 、 Dorsal root ganglion 、 Invariant natural killer T-cell 、 Mutant 、 Globoside 、 In vivo 、 Immunology 、 Ligand 、 Cell biology 、 Biology 、 Glycosphingolipid
摘要: Development of invariant natural killer T (iNKT) cells requires the presentation lipid ligand(s) by CD1d molecules in thymus. The glycosphingolipid (GSL) isoglobotrihexosylceramide (iGb3) has been proposed as iNKT cell-selecting ligand thymus and to be involved peripheral activation dendritic (DCs). However, there is no direct biochemical evidence for presence iGb3 mouse or human DCs. Using a highly sensitive HPLC assay, only tissue where could detected was dorsal root ganglion (DRG). not other any tissues analyzed, including Even mutant mice that store isoglobo-series GSLs DRG, we were still unable detect these therefore unlikely physiologically relevant humans. A detailed study now warranted better understand nature vivo.
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