Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis.

摘要: Neurohumoral modulation of cardiovascular function is an important component the hemodynamic alterations in patients with chronic congestive heart failure (CHF). Analysis rate (HR) variability a noninvasive means investigating autonomic control heart. The HR and respiratory signals, both derived from ambulatory electrocardiographic recordings, were analyzed power spectral analysis to evaluate 25 stable CHF (class III or IV) 21 normal subjects. In CHF, was markedly reduced (p less than 0.0001) at all frequencies examined (0.01 1.0 Hz, period 1 100 seconds) virtually absent greater 0.04 Hz. Heart fluctuations very low Hz) effectively differentiated subjects, due discrete (about 65 seconds, 0.015 oscillation HR, which associated similar pattern activity many CHF. These findings demonstrate marked derangement severe frequency characteristics these are consistent abnormal baroreflex responsiveness physiologic stimuli, suggest that there diminished vagal, but relatively preserved sympathetic, HR.