Cortical excitability after pediatric mild traumatic brain injury.

摘要: Abstract Introduction Mild traumatic brain injury (mTBI) outcomes are variable, and 10–15% may suffer from prolonged symptoms beyond 3 months that impair the child's return to normal activities. Neurophysiological mechanisms of mTBI incompletely understood, particularly in children, but alterations cortical excitability have been proposed underlie post-concussion syndrome. Improved understanding is required advance interventions improve outcomes. Objective/Hypothesis To determine if altered children with mTBI, its association clinical symptoms. Methods This was a cross-sectional controlled cohort study. School-aged (8–18 years) were compared healthy controls. Cortical measured using multiple TMS paradigms (symptomatic) without (recovered) persistent one-month post-injury. Primary outcome silent period (cSP), potential neurophysiological biomarker GABAergic inhibition. Secondary included additional neurophysiology, safety tolerability. Associations between neurophysiology parameters evaluated. Results Fifty-three (55% male; mean age 14.1 SD: 2.4 years; 35 symptomatic 27 asymptomatic participants) 28 controls (46% 14.3 3.1 enrolled. cSP duration similar groups (F (2, 73) = 0.55, p = 0.582). Log 10 long interval intracortical inhibition (LICI) reduced participants 59) = 3.83, p = 0.027). Procedures well tolerated no serious adverse events. Conclusions measures at one month mTBI. Long decreased who remain