Oxidative Bond-Cleavage Reactions in Nature - Mechanistic and Ecological Aspects

摘要: Oxidative bond cleavage reactions provide a general pathway to olefinic substructures within biomolecules. The span of individual transformations ranges from the decarboxylation fatty acids cyclic and acyclic precursors dealkylations in field steroids. Stereochemical studies using deuterium labelled mass spectroscopic analysis metabolites could be used unravel mechanistic details biosynthesis 1-alkenes plants insects, algal pheromones homoterpenes without need for isolation enzymes. INTRODUCTION introduction double bonds into saturated is fundamental process cellular metabolism. majority such achieved by either direct removal two vicinal hydrogen atoms precursor "desaturases" or heteroatomic moiety together with atom. latter reaction catalyzed plethora different "lyases". 2 [HI c--"'6: HX X = H R2 x -OR, -SR, -NR2 lyases I dehydrogenases A special case "1yase"-activities observed substrates where departing group part carbon skeleton (eqn. 1).