Imaging of a clickable anticancer iridium catalyst.
作者： Xiuxiu Wang , Mingli Zhu , Fei Gao , Wei Wei , Yong Qian
DOI: 10.1016/J.JINORGBIO.2017.12.019
关键词: Combinatorial chemistry 、 Reagent 、 Cytotoxicity 、 Azide 、 Nitrone 、 Catalysis 、 Chemistry 、 Iridium 、 Ligand 、 Cycloaddition
摘要: Abstract Iridium-based anticancer reagents are receiving increasing attention for their high cytotoxicity. Herein, by activating C H bonds in the well-known antioxidant α-phenyl- N -tert-butylnitrone (PBN), we synthesized and characterized a series of new iridium complexes. Complex 1-AMP exhibited best antiproliferation activity towards human ovarian cancer A2780 cells. The azide group complex underwent Cu(I)-catalysed azide − alkyne cycloaddition (CuAAC) reaction resulting fluorescent imaging cells suggested it mainly accumulated mitochondria. In comparison, to eliminate cytotoxicity Cu(I) catalyst, conducted between commercialized dye via strain-promoted alkyne–azide (SPAAC) live cells, confirming its targeting complexes containing nitrone ligand may offer useful tool probe mechanism metallodrugs.
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