The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury.
作者： Olga Ruiz-Andres , Beatriz Suarez-Alvarez , Cristina Sánchez-Ramos , Maria Monsalve , Maria D Sanchez-Niño
DOI: 10.1038/KI.2015.332
关键词: Downregulation and upregulation 、 Mitochondrial biogenesis 、 Biology 、 Immunology 、 TFAM 、 Cancer research 、 NDUFS1 、 Mitochondrion 、 Kidney metabolism 、 Histone H3 deacetylation 、 Cytokine TWEAK
摘要: … of PGC-1α and PGC-1α target genes encoding mitochondrial … TWEAK also reduces the expression of PGC-1α and target … deacetylation, resulting in impaired mitochondrial function. …
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