The antiviral activity of antibodies in vitro and in vivo.

摘要: Publisher Summary This chapter discusses in vitro and vivo antiviral activities of antibody. Since experimentation is far easier , researchers have been sought to develop assays that are expected predict activity . could be important both vaccine design passive antibody administration. The proposed mechanisms neutralization range from those requiring binding a single molecule virus substantially complete coating virus. In vitro, can separated into against virions infected cells. most often considered defined as the loss infectivity, which ensues when molecule(s) bind particle, occurs without involvement any other agency. vivo, it conventional distinguish phenomenologically between two types activity. One them ability protect infection present before or immediately following infection. Evidence for number viruses indicates lower concentrations required inhibit propagated by free than cell-to-cell spread.