Immunotoxicological profile of chloroform in female B6C3F1 mice when administered in drinking water.
作者： Wimolnut Auttachoat , Dori R. Germolec , Bradley J. Collins , Robert W. Luebke , Kimber L. White
DOI: 10.1080/01480540802433880
关键词: Splenocyte 、 Chloroform 、 Water treatment 、 Chemistry 、 Humoral immunity 、 Physiology 、 Innate immune system 、 Water chlorination 、 Internal medicine 、 Toxicology 、 Hematology 、 Immunity
摘要: Chloroform can be formed as a disinfection by-product during water chlorination, one of the primary modalities for purifying municipal supplies human consumption. The aim this study was to characterize immunotoxic effects chloroform in female B6C3F1 mice when exposure occurred via drinking water. Consistent with exposure, were exposed chloroform-containing at 2.5, 10, 25, 100, and 250 ppm 28 days. examined endpoints included on body organ weights, consumption, hematology, innate immunity, humoral cell-mediated immunity. functions natural killer, B-, T-cells not altered by concentrations tested, except that an increase splenocyte basal proliferation observed levels 100 ppm. Following administration, there decreased number circulating neutrophils blood all treatment groups...
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informapharmascience.com参考文章(40)
C W Reynolds, R B Herberman, In vitro augmentation of rat natural killer (NK) cell activity. Journal of Immunology. ,vol. 126, pp. 1581- 1585 ,(1981)
Lance A. Wallace, Edo Pellizzari, Ty Hartwell, Martin Rosenzweig, Mitchell Erickson, Charles Sparacino, Harvey Zelon, Personal exposure to volatile organic compounds: I. Direct measurements in breathing-zone air, drinking water, food, and exhaled breath☆ Environmental Research. ,vol. 35, pp. 293- 319 ,(1984) , 10.1016/0013-9351(84)90137-3
C J Czuprynski, J F Brown, R D Wagner, H Steinberg, Administration of antigranulocyte monoclonal antibody RB6-8C5 prevents expression of acquired resistance to Listeria monocytogenes infection in previously immunized mice. Infection and Immunity. ,vol. 62, pp. 5161- 5163 ,(1994) , 10.1128/IAI.62.11.5161-5163.1994
P S Morahan, P C Klykken, S H Smith, L S Harris, A E Munson, Effects of cannabinoids on host resistance to Listeria monocytogenes and herpes simplex virus. Infection and Immunity. ,vol. 23, pp. 670- 674 ,(1979) , 10.1128/IAI.23.3.670-674.1979
Jeffrey L. Larson, Douglas C. Wolf, Byron E. Butterworth, Induced regenerative cell proliferation in livers and kidneys of male F-344 rats given chloroform in corn oil by gavage or ad libitum in drinking water Toxicology. ,vol. 95, pp. 73- 86 ,(1995) , 10.1016/0300-483X(94)02886-Y
Masarin Ban, Denise Hettich, Pierre Bonnet, Effect of inhaled industrial chemicals on systemic and local immune response Toxicology. ,vol. 184, pp. 41- 50 ,(2003) , 10.1016/S0300-483X(02)00553-X
J Larson, The Toxicity of 1-Week Exposures to Inhaled Chloroform in Female B6C3F1 Mice and Male F-344 Rats Fundamental and Applied Toxicology. ,vol. 22, pp. 431- 446 ,(1994) , 10.1006/FAAT.1994.1049
R J Bull, J M Brown, E A Meierhenry, T A Jorgenson, M Robinson, J A Stober, Enhancement of the hepatotoxicity of chloroform in B6C3F1 mice by corn oil: implications for chloroform carcinogenesis. Environmental Health Perspectives. ,vol. 69, pp. 49- 58 ,(1986) , 10.1289/EHP.866949
M Pereira, Route of Administration Determines Whether Chloroform Enhances or Inhibits Cell Proliferation in the Liver of B6C3F1 Mice Fundamental and Applied Toxicology. ,vol. 23, pp. 87- 92 ,(1994) , 10.1006/FAAT.1994.1083
JA Haines, International programme on chemical safety The Lancet. ,vol. 348, pp. 408- 409 ,(1996) , 10.1016/S0140-6736(05)65029-5