Dogs really are man's best friend—Canine genomics has applications in veterinary and human medicine!
作者： Mike P Starkey , Timothy J Scase , Cathryn S Mellersh , Sue Murphy , None
DOI: 10.1093/BFGP/4.2.112
关键词: Human medicine 、 Biology 、 Human disease 、 MEDLINE 、 Genomics 、 Disease 、 Family medicine
摘要: In 2003, the US National Human Genome Research Institute (NHGRI) agreed to fund a project sequence entire genome of boxer dog named Tasha. Although USA is country lovers, with approximately 38 million households owning one or more dogs, why did Institutes Health countenance use $30m for such purpose? The answer that NHGRI recognised value as an unrivalled model study human disease. this paper, reasons good are examined. Examples where disease in dogs increasing understanding genetic basis disease, development improved diagnostic assays and evaluation clinical therapies provided.
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Prohaska, Genetic diseases of copper metabolism. Clinical physiology and biochemistry. ,vol. 4, pp. 87- 93 ,(1986)
Arthur S. Foutz, Merrill M. Mitler, Luigi L. Cavalli-Sforza, William C. Dement, Genetic factors in canine narcolepsy. Sleep. ,vol. 1, pp. 413- 421 ,(1978) , 10.1093/SLEEP/1.4.413
Smith Mo, Winchester Bg, Sargan Dr, Skelly Bj, Herrtage Me, Giger U, Genomic screening for fucosidosis in English Springer Spaniels. American Journal of Veterinary Research. ,vol. 60, pp. 726- 729 ,(1999)
Simon M. Petersen-Jones, David R. Sargan, David D. Entz, cGMP phosphodiesterase-α mutation causes progressive retinal atrophy in the Cardigan Welsh corgi dog Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 1637- 1644 ,(1999)
Barbara Zangerl, Elaine A. Ostrander, Gregory M. Acland, Jennifer L. Johnson, Gustavo D. Aguirre, Caroline J. Zeiss, Caroline J. Zeiss, Zuohua Mao, Zuohua Mao, Qi Zhang, Fine Mapping of Canine XLPRA Establishes Homology of the Human and Canine RP3 Intervals Investigative Ophthalmology & Visual Science. ,vol. 42, pp. 2466- 2471 ,(2001)
J. Kijas, G. Acland, O. Goldstein, J. Nelson, D. Sidjanin, G. Aguirre, A Linkage Disequilibrium Map of the Progressive Rod Cone Degeneration Interval Investigative Ophthalmology & Visual Science. ,vol. 45, pp. 4756- 4756 ,(2004)
Thomas H. Rhodes, Charles H. Vite, Urs Giger, Donald F. Patterson, Christoph Fahlke, Alfred L. George, A missense mutation in canine ClC-1 causes recessive myotonia congenita in the dog1 FEBS Letters. ,vol. 456, pp. 54- 58 ,(1999) , 10.1016/S0014-5793(99)00926-6
Matthew Breen, Joern Bullerdiek, Cordelia F. Langford, The DAPI banded karyotype of the domestic dog (Canis familiaris) generated using chromosome-specific paint probes. Chromosome Research. ,vol. 7, pp. 401- 406 ,(1999) , 10.1023/A:1009224232134
Fengtang Yang, Alexander S. Graphodatsky, Patricia C. M. O'Brien, Amanda Colabella, Nita Solanky, Michael Squire, David R. Sargan, Malcolm A. Ferguson-Smith, Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human. Chromosome Research. ,vol. 8, pp. 393- 404 ,(2000) , 10.1023/A:1009210803123
Z. H. Wang, B. Zeng, H. Shibuya, G. S. Johnson, J. Alroy, G. M. Pastores, S. Raghavan, E. H. Kolodny, Isolation and characterization of the normal canine β-galactosidase gene and its mutation in a dog model of GM1-gangliosidosis Journal of Inherited Metabolic Disease. ,vol. 23, pp. 593- 606 ,(2000) , 10.1023/A:1005630013448