Immunohistochemical staining for Ki-67 antigen, carcinoembryonic antigen, and p53 in the differential diagnosis of glandular lesions of the cervix.

摘要: Cytoplasmic carcinoembryonic antigen (CEA) positivity assists in the distinction of benign and malignant glandular lesions cervix, but some cases remain problematic. The accumulation p53 protein an increased proliferative index, as measured by expression Ki-67 antigen, have not been used adjuncts to diagnosis these lesions. Immunohistochemical stains for CEA, protein, were performed on 31 formalin-fixed, paraffin-embedded endocervical including invasive adenocarcinoma, adenocarcinoma situ, adenoma malignum, tunnel clusters, florid microglandular hyperplasia, mesonephric remnants, atypical normal controls. was quantitated negligible, low, moderate, or high basis percentage ( 40%, respectively) nuclei that positive with MIB-1 antibody. Strong staining more than 10% epithelial interpreted overexpression. CEA determined either diffuse focal cytoplasmic columnar cells equalling glycocalyceal intensity. combination a moderate-to-high index limited compared (P = 0.005). A and/or features rather mimickers; there no false positives negatives. Similarly, only neoplasms shared overexpression 0.043). is diagnostic malignancy With exception seen neoplastic endocervix. An immunohistochemical battery consisting (Ki-67), useful discriminating between