High-level expression of receptor tyrosine kinase Ret and responsiveness to Ret-activating ligands in pheochromocytoma cell lines from neurofibromatosis knockout mice.

摘要: Pheochromocytoma cell lines derived from neurofibromatosis knockout mice express high levels of the receptor tyrosine kinase Ret, which is involved in pathogenesis human pheochromocytomas hereditary multiple endocrine neoplasia syndrome type 2 (MEN2). Mouse pheochromocytoma (MPC) cells respond to Ret-activating ligand GDNF by exhibiting Ret phosphorylation, neurite outgrowth, decreased proliferation, and altered expression catecholamine biosynthetic enzymes. exerts similar effects on primary cultures. minimally expressed normal mouse chromaffin cells, are derived. Its at MPC suggests possible relationships between two previously unrelated tumor syndromes, neurofibromatosis, MEN2. The responsiveness these that they may be a valuable new model for neurobiology.