Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants
作者： K.Peter Lesch , Charanjit S. Aulakh , Benjamin L. Wolozin , Teresa J. Tolliver , James L. Hill
DOI: 10.1016/0169-328X(93)90069-2
关键词: Pharmacology 、 Transporter 、 Serotonin 、 Endocrinology 、 Reuptake inhibitor 、 Mechanism of action 、 Biology 、 Serotonin transporter 、 Reuptake 、 Antidepressant 、 Internal medicine 、 Norepinephrine transporter 、 Molecular biology 、 Cellular and Molecular Neuroscience
摘要: Regional expression and antidepressant drug-induced regulation of mRNA encoding the serotonin (5-HT) transporter were studied in rat brain. While 5-HT is abundantly expressed midbrain raphe complex, lower concentrations also found frontal cortex, hippocampus, neostriatum using a combination reverse transcriptase-polymerase chain reaction (RT-PCR), Southern hybridization, sequence analysis. Long-term administration antidepressants which inhibit reuptake, but not monoamine oxidase inhibitors or receptor agonists, decrease steady-state concentrations. Based on these observations, we conclude that (1) coding for present several brain areas associated with ascending HT pathways, (2) chronic treatment reuptake inhibiting may be at level gene contribute to neuroadaptive mechanisms likely underlie their therapeutic efficacy.
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