Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia
作者： Axel M. Hillmer , Sandra Hanneken , Sibylle Ritzmann , Tim Becker , Jan Freudenberg
DOI: 10.1086/431425
关键词: Androgen receptor 、 Genetics 、 Genetic variation 、 Hair loss 、 Major gene 、 Genetic predisposition 、 Genetic marker 、 Locus (genetics) 、 Biology 、 Genetic variability
摘要: Androgenetic alopecia (AGA), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis androgen dependent, and genetic predisposition major requirement for phenotype. We demonstrate that variability in receptor gene (AR) cardinal prerequisite development early-onset AGA, with an etiological fraction 0.46. The investigation a large number variants covering AR locus suggests polyglycine-encoding GGN repeat exon 1 plausible candidate conferring functional effect. X-chromosomal location stresses importance maternal line inheritance AGA.
core.ac.uk
hud.ac.uk
elsevier.com
mdc-berlin.de
sci-hub.se 参考文章(41)
OʼTAR T. NORWOOD, Male pattern baldness: classification and incidence. Southern Medical Journal. ,vol. 68, pp. 1359- 1365 ,(1975) , 10.1097/00007611-197511000-00009
P.W. Faber, H.C. van Rooij, H.J. Schipper, A.O. Brinkmann, J. Trapman, Two different, overlapping pathways of transcription initiation are active on the TATA-less human androgen receptor promoter. The role of Sp1. Journal of Biological Chemistry. ,vol. 268, pp. 9296- 9301 ,(1993) , 10.1016/S0021-9258(18)98349-3
P C Supakar, C S Song, M H Jung, M A Slomczynska, J M Kim, R L Vellanoweth, B Chatterjee, A K Roy, A novel regulatory element associated with age-dependent expression of the rat androgen receptor gene. Journal of Biological Chemistry. ,vol. 268, pp. 26400- 26408 ,(1993) , 10.1016/S0021-9258(19)74328-2
P.W. Faber, H.C. van Rooij, H.A. van der Korput, W.M. Baarends, A.O. Brinkmann, J.A. Grootegoed, J. Trapman, Characterization of the human androgen receptor transcription unit. Journal of Biological Chemistry. ,vol. 266, pp. 10743- 10749 ,(1991) , 10.1016/S0021-9258(18)99080-0
Harry Ostrer, Maurice P. Zeegers, Lambertus A.L.M. Kiemeney, Alan M. Nieder, How Strong Is the Association Between CAG and GGN Repeat Length Polymorphisms in the Androgen Receptor Gene and Prostate Cancer Risk Cancer Epidemiology, Biomarkers & Prevention. ,vol. 13, pp. 1765- 1771 ,(2004)
Ernest Hawk, Rosalind A. Breslow, Barry I. Graubard, Male Pattern Baldness and Clinical Prostate Cancer in the Epidemiologic Follow-Up of the First National Health and Nutrition Examination Survey Cancer Epidemiology, Biomarkers & Prevention. ,vol. 9, pp. 523- 527 ,(2000)
R Nagaraja, S MacMillan, J Kere, C Jones, S Griffin, M Schmatz, J Terrell, M Shomaker, C Jermak, C Hott, M Masisi, S Mumm, A Srivastava, G Pilia, T Featherstone, R Mazzarella, S Kesterson, B McCauley, B Railey, F Burough, V Nowotny, M D'Urso, D States, B Brownstein, D Schlessinger, X chromosome map at 75-kb STS resolution, revealing extremes of recombination and GC content. Genome Research. ,vol. 7, pp. 210- 222 ,(1997) , 10.1101/GR.7.3.210
Hideto Nakajima, Fumiharu Kimura, Toshimasa Nakagawa, Daisuke Furutama, Keiichi Shinoda, Akira Shimizu, Nakaaki Ohsawa, Transcriptional activation by the androgen receptor in X-linked spinal and bulbar muscular atrophy Journal of the Neurological Sciences. ,vol. 142, pp. 12- 16 ,(1996) , 10.1016/0022-510X(96)00142-6
Masahiro Sasaki, Akihiro Karube, Yuko Karube, Michiko Watari, Noriaki Sakuragi, Seiichiro Fujimoto, Rajvir Dahiya, GGC and StuI polymorphism on the androgen receptor gene in endometrial cancer patients. Biochemical and Biophysical Research Communications. ,vol. 329, pp. 100- 104 ,(2005) , 10.1016/J.BBRC.2005.01.104
Veikko Matilainen, Pentti Koskela, Sirkka Keinänen-Kiukaanniemi, Early androgenetic alopecia as a marker of insulin resistance. The Lancet. ,vol. 356, pp. 1165- 1166 ,(2000) , 10.1016/S0140-6736(00)02763-X