Method of detecting genetic translocations identified with chromosomal abnormalities
作者： Daniel Pinkel , Joe W. Gray , Douglas Tkachuk
DOI:
关键词: Nucleic acid 、 Nucleic acid sequence 、 Chronic myelogenous leukemia 、 Genetics 、 Chromosomal translocation 、 Biology 、 Metaphase 、 Staining 、 Stain 、 Cytogenetics
摘要: Methods and compositions for staining based upon nucleic acid sequence that employ probes are provided. Said methods produce patterns can be tailored specific cytogenetic analyses. appropriate in situ hybridization stain both interphase metaphase chromosomal material with reliable signals. The typically of a complexity greater than 50 kb, the depending application. reagents provided detection genetic rearrangements. Probes test kits use detecting rearrangements, particularly tumor cytogenetics, disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) biological dosimetry. described research, differentiation cytogenetically similar but genetically different diseases, many prognostic diagnostic applications.
osti.gov
google.co.in 参考文章(173)
Ian Dubé, Julie Dixon, Teresa Beckett, Abraham Grossman, Martha Weinstein, Peter Benn, Timothy McKeithan, Con Norman, Peter Pinkerton, Location of breakpoints within the major breakpoint cluster region (bcr) in 33 patients with bcr rearrangement-positive chronic myeloid leukemia (CML) with complex or absent Philadelphia chromosomes. Genes, Chromosomes and Cancer. ,vol. 1, pp. 106- 111 ,(1989) , 10.1002/GCC.2870010116
Stanley F. Nelson, John H. McCusker, Mark A. Sander, Yun Kee, Paul Modrich, Patrick O. Brown, Genomic mismatch scanning: a new approach to genetic linkage mapping. Nature Genetics. ,vol. 4, pp. 11- 18 ,(1993) , 10.1038/NG0593-11
Nora Heisterkamp, Eva Knoppel, John Groffen, The first BCR gene intron contains breakpoints in Philadelphia chromosome positive leukemia. Nucleic Acids Research. ,vol. 16, pp. 10069- 10081 ,(1988) , 10.1093/NAR/16.21.10069
M. Litt, R. L. White, A highly polymorphic locus in human DNA revealed by cosmid-derived probes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 6206- 6210 ,(1985) , 10.1073/PNAS.82.18.6206
Nora Heisterkamp, Kees Stam, John Groffen, Annelies de Klein, Gerard Grosveld, Structural organization of the bcr gene and its role in the Ph' translocation. Nature. ,vol. 315, pp. 758- 761 ,(1985) , 10.1038/315758A0
T. P. Dryja, J. M. Rapaport, J. M. Joyce, R. A. Petersen, Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 7391- 7394 ,(1986) , 10.1073/PNAS.83.19.7391
Richard M. Lawn, Edward F. Fritsch, Richard C. Parker, Geoffrey Blake, Tom Maniatis, The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA Cell. ,vol. 15, pp. 1157- 1174 ,(1978) , 10.1016/0092-8674(78)90043-0
Laura Manuelidis, Individual interphase chromosome domains revealed by in situ hybridization Human Genetics. ,vol. 71, pp. 288- 293 ,(1985) , 10.1007/BF00388453
Y Ben-Neriah, G. Daley, A. Mes-Masson, O. Witte, D Baltimore, The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene. Science. ,vol. 233, pp. 212- 214 ,(1986) , 10.1126/SCIENCE.3460176
P. J. A. Sondermeijer, N. H. Lubsen, The activity of two heat shock loci of Drosophila hydei in tissue culture cells and salivary gland cells as analyzed by in situ hybridization of complementary DNA Chromosoma. ,vol. 72, pp. 281- 291 ,(1979) , 10.1007/BF00331090