A Comparative Study of Inner Membrane Enzymes and Transport Systems in Mitochondria from R3230AC Mammary Tumor and Normal Rat Mammary Gland

摘要: Mitochondria from a rat mammary tumor (R3230AC) have been compared with mitochondria pregnant and lactating glands, particular attention paid to inner membrane enzymes Transport proteins. In the mitochondrial adenosine triphosphatase was not activated by 2,4-dinitrophenol, in contrast or rats. Translocation of diphosphate across found be more rapid virtue lovered Km raised Vmax. phosphate dicarboxylic acids occurred at similar rates all three types mitochondria. The proteins were also examined directly sodium dodecyl sulfate/polyacrylamide gel electrophoresis some differences are noted. These results, although they indicate subtle between membranes as those cannot form basis an explanation for enhanced glucose utilization aerobic lactic acid production this tumor.