Iminodiacetate as a didentate ligand: base induced dealkylation
作者： Richard M. Hartshorn
DOI: 10.1039/B203597A
关键词: Alkylation 、 Glycine 、 Amino acid 、 Chemistry 、 Stereochemistry 、 Chelation 、 Medicinal chemistry 、 Ligand 、 Base (chemistry) 、 Reaction conditions 、 Imine
摘要: Iminodiacetate has been incorporated into a complex as didentate ligand. Control of pH is vital to the successful synthesis complex. At > 8 glycinato complexes have observed be significant products from synthesis. Evidence presented in support proposal that glycine results oxidative dealkylation coordinated iminodiacetate. An imine similar possible intermediate this reaction prepared and shown give rise amino acid on submission conditions. The are formed derived either pendant or chelated parts Possible mechanisms discussed.
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