The Efficiency of the Formation of Singlet Oxygen by a Sensitizer Based on Zinc Phthalocyanine
作者： N. E. Koval'skaya , N. A. Kuznetsova , O. L. Kaliya , N. S. Gretsova , I. V. Sokolova
关键词: Zinc phthalocyanine 、 Buffer solution 、 Photochemistry 、 Inorganic chemistry 、 Phthalocyanine 、 Zinc 、 Photodynamic therapy 、 Biomolecule 、 Singlet oxygen 、 Quantum yield 、 Chemistry
摘要: Using zinc octa(diethoxyphosphenylmethyl)phthalocyanine as an example, we determined experimentally the quantum yield of generation singlet oxygen (ϕΔ) which makes it possible to evaluate quantitatively efficiency photogeneration 1O2 and influence biomolecules on this parameter. It is shown that by sensitizers used in photodynamic therapy depends their state a solution increases with disaggregation dye its interaction biomolecules. established phthalocyanine aqueous buffer sensitizes formation ϕΔ = 0.16 ± 0.02. On introduction detergent Triton X‐100 into phthalocyanine, up 0.48 0.07. In microheterogeneous medium (buffer + albumin) 0.42.
springer.com
sci-hub.se 参考文章(6)
Ionel Rosenthal, Phthalocyanines as photodynamic sensitizers. Photochemistry and Photobiology. ,vol. 53, pp. 859- 870 ,(1991) , 10.1111/J.1751-1097.1991.TB09900.X
Samir Kumar Pal, Debabrata Mandal, Dipankar Sukul, Kankan Bhattacharyya, Photoinduced electron transfer between dimethylaniline and oxazine 1 in micelles principles and practice of constraint programming. ,vol. 249, pp. 63- 71 ,(1999) , 10.1016/S0301-0104(99)00270-0
Jorge Davila, Anthony Harriman, Photosensitized oxidation of biomaterials and related model compounds. Photochemistry and Photobiology. ,vol. 50, pp. 29- 35 ,(1989) , 10.1111/J.1751-1097.1989.TB04126.X
I. Rosenthal, C. Murali Krishna, P. Riesz, E. Ben-Hur, The role of molecular oxygen in the photodynamic effect of phthalocyanines. Radiation Research. ,vol. 107, pp. 136- 142 ,(1986) , 10.2307/3576857
Raymond Bonnett, Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy Chemical Society Reviews. ,vol. 24, pp. 19- 33 ,(1995) , 10.1039/CS9952400019
Ian R. Hart, Wai-Shun Chan, John F. Marshall, Joanne Bedwell, Russel Svensen, Effect of sulfonation on the cell and tissue distribution of the photosensitizer aluminum phthalocyanine. Cancer Research. ,vol. 50, pp. 4533- 4538 ,(1990)