Juvenile chronic myelogenous leukemia.

摘要: Juvenile chronic myelogenous leukemia (JCML) is an aggressive myeloproliferative disorder of childhood that differs both clinically and pathologically from adult type, Philadelphia chromosome positive leukemia, the other disorders are more common in adulthood. The disease can have widely varying clinical presentations shares many features with monosomy 7 syndrome myelomonocytic leukemia. With no specific marker chromosome, establishing diagnosis be difficult, relies on a constellation clinical, pathologic, laboratory findings. This article discusses differential JCML emphasis pathologic findings data particularly important for confirming diagnosis. sensitivity, specificity, utility cell culture colony assays reviewed. Finally, current knowledge biology some controversies regarding this discussed.