Early-Life Physical Activity and Postmenopausal Breast Cancer: Effect of Body Size and Weight Change

摘要: It is not yet known whether early-life physical activity reduces the risk of developing breast cancer. Subgroup analyses according to menopausal status and body mass may help clarify this association. Data from a population-based case-control study female residents Wisconsin, Massachusetts, Maine, New Hampshire were used examine associations between cancer risk. Cases (n = 4614) identified by each state's tumor registry; controls 5817) randomly selected population lists. Frequency participation in strenuous when 14-22 years age, weight at age 18 5 before interview, height, other factors ascertained through structured telephone interviews. Adjusted odds ratios (ORs) 95% confidence intervals (CIs) computed using logistic regression. Reductions postmenopausal associated with greatest for women fourth quartile index 18; OR highest frequency on average (> or =once/day) was 0.45 (95% CI 0.26-0.79). Associations also varied change. Compared no little adult gain, frequent reduced who had lost since (OR 0.19, 0.05-0.70) gained modest amounts (weight gain: first tertile, 0.36, 0.05-0.85; second 0.31, 0.14-0.66). Weighted MET score yielded similar but less inverse results. These findings suggest that frequent, be who, over years, either only amounts.