Prevalence and Genomic Diversity of Feline Leukemia Virus in Privately Owned and Shelter Cats in Aburrá Valley, Colombia.

作者: Carolina Ortega , Alida C. Valencia , July Duque-Valencia , Julián Ruiz-Saenz

DOI: 10.3390/V12040464

关键词: VirusVirologyMolecular variationSerologyFeline leukemia virusPopulationRetrovirusCATSLeukemiaBiology

摘要: The feline leukemia virus (FeLV) belongs to the family Retroviridae; it is first retrovirus discovered and one of agents that has a great impact on cats’ health ecology population worldwide. It associated with occurrence several syndromes fatal diseases, including development lymphomas. Studies FeLV have been reported in Colombia, most them approached from clinical point view. However, only few studies focused prevalence infection, while none clarified which variant or viral subgroup presently circulating our country. Therefore, present study investigated infection molecular characterization cats Aburra Valley, Colombia. sampling privately owned shelter was performed female (n = 54) male 46) felines; were seemingly healthy according owner’s report, nonspecific history. Immunoassay confirmed 59.44% (95% confidence interval (CI) 49.81–69.06%) felines seropositive. testing using reverse transcription–polymerase chain reaction sequencing showed 30% (30/100) positive, prevalent Valley FeLV-A. In conclusion, frequency virus, as revealed by serological tests, highest frequencies date, high variation shown Colombian population. More behaviour populations Columbia are warranted determine its throughout

参考文章(35)
J. C. Neil, R. Fulton, M. Rigby, M. Stewart, Feline Leukaemia Virus: Generation of Pathogenic and Oncogenic Variants Current Topics in Microbiology and Immunology. ,vol. 171, pp. 67- 93 ,(1991) , 10.1007/978-3-642-76524-7_4
J. F. Calle-Restrepo, L. M. Morales-Zapata, J. Ruiz-Sáenz, L. Fernández-González, Feline leukemia virus: a current pathogen requiring attention in Colombia. Veterinaria y Zootecnia. ,vol. 7, pp. 117- 138 ,(2013)
Hazel Stewart, Karen W Adema, Elizabeth L McMonagle, Margaret J Hosie, Brian J Willett, Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus. Retrovirology. ,vol. 9, pp. 48- 48 ,(2012) , 10.1186/1742-4690-9-48
Edward A. Hoover, James P. Ebner, Nordin S. Zeidner, James I. Mullins, Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonyl-methoxyethyl)adenine (PMEA) Antiviral Research. ,vol. 16, pp. 77- 92 ,(1991) , 10.1016/0166-3542(91)90060-5
James I. Mullins, Edward A. Hoover, Julie Overbaugh, Sandra L. Quackenbush, Peter R. Donahue, Mary L. Poss, FeLV-FAIDS-induced immunodeficiency syndrome in cats. Veterinary Immunology and Immunopathology. ,vol. 21, pp. 25- 37 ,(1989) , 10.1016/0165-2427(89)90127-X
Jessica M. Quimby, Thomas Elston, Jennifer Hawley, Melissa Brewer, Arianne Miller, Michael R. Lappin, Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. Journal of Feline Medicine and Surgery. ,vol. 10, pp. 66- 72 ,(2008) , 10.1016/J.JFMS.2007.05.007
Andrew J. Phipps, Kathleen A. Hayes, Musaad Al-dubaib, Pradip Roy-Burman, Lawrence E. Mathes, Inhibition of Feline Leukemia Virus Subgroup A Infection by Coinoculation with Subgroup B Virology. ,vol. 277, pp. 40- 47 ,(2000) , 10.1006/VIRO.2000.0606
Katrin Hartmann, Clinical Aspects of Feline Retroviruses: A Review Viruses. ,vol. 4, pp. 2684- 2710 ,(2012) , 10.3390/V4112684
Stephen P. Dunham, Elizabeth Graham, Retroviral infections of small animals. Veterinary Clinics of North America-small Animal Practice. ,vol. 38, pp. 879- 901 ,(2008) , 10.1016/J.CVSM.2008.03.005
J. Overbaugh, E.A. Hoover, J.I. Mullins, D.P.W. Burns, L. Rudensey, S.L. Quackenbush, V. Stallard, P.R. Donahue, Structure and pathogenicity of individual variants within an immunodeficiency disease-inducing isolate of FeLV. Virology. ,vol. 188, pp. 558- 569 ,(1992) , 10.1016/0042-6822(92)90510-V