Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer
作者： Ti-Dong Shan , Ji-Hao Xu , Tao Yu , Jie-Yao Li , Lin-Na Zhao
关键词: Gene knockdown 、 Cancer research 、 Autophagy 、 Biology 、 Immunology 、 Signal transduction 、 Cell cycle 、 Cyclin D1 、 Epithelial–mesenchymal transition 、 Intrinsic apoptosis 、 Cell growth
摘要: Long intergenic noncoding RNAs (lincRNAs) play important roles in regulating the biological functions and underlying molecular mechanisms of colorectal cancer (CRC). Here, we investigated association linc-POU3F3 prognosis CRC. We demonstrated that was overexpressed CRC tissues positively correlated with tumor grade N stage. Inhibition resulted inhibition cell proliferation G1 cycle arrest, which mediated by cyclin D1, CDK4, p18, Rb, phosphorylated Rb. induced apoptosis, suppressed migration invasion LOVO SW480 lines. This also increased expressions epithelial markers decreased mesenchymal markers, thus inhibiting epithelial-mesenchymal transition. The following knockdown were an BMP signal. Furthermore, autophagy enhanced knockdown, suggesting involvement apoptosis. Collectively, might be crucial pro-proliferation, anti-apoptosis, metastasis cells cycle, intrinsic signaling autophagy. Thus, is a potential therapeutic target novel biomarker for
impactjournals.com参考文章(47)
N Kyprianou, M V Fiandalo, Caspase control: protagonists of cancer cell apoptosis Experimental Oncology. ,vol. 34, pp. 165- 175 ,(2012)
Mariam Aghajan, Ning Li, Michael Karin, Obesity, autophagy and the pathogenesis of liver and pancreatic cancers Journal of Gastroenterology and Hepatology. ,vol. 27, pp. 10- 14 ,(2012) , 10.1111/J.1440-1746.2011.07008.X
Avital Eisenberg-Lerner, Adi Kimchi, The paradox of autophagy and its implication in cancer etiology and therapy Apoptosis. ,vol. 14, pp. 376- 391 ,(2009) , 10.1007/S10495-008-0307-5
Sheng-Hui Lan, Shan-Ying Wu, Roberto Zuchini, Xi-Zhang Lin, Ih-Jen Su, Ting-Fen Tsai, Yen-Ju Lin, Cheng-Tao Wu, Hsiao-Sheng Liu, Autophagy-preferential degradation of MIR224 participates in hepatocellular carcinoma tumorigenesis Autophagy. ,vol. 10, pp. 1687- 1689 ,(2014) , 10.4161/AUTO.29959
Liudmila L. Kodach, Eliza Wiercinska, Noel F.C.C. de Miranda, Sylvia A. Bleuming, Alex R. Musler, Maikel P. Peppelenbosch, Evelien Dekker, Gijs R. van den Brink, Carel J.M. van Noesel, Hans Morreau, Daniel W. Hommes, Peter ten Dijke, G. Johan A. Offerhaus, James C.H. Hardwick, The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers Gastroenterology. ,vol. 134, pp. 1332- 1341.e3 ,(2008) , 10.1053/J.GASTRO.2008.02.059
Wei Li, Jian Zheng, Jieqiong Deng, Yonghe You, Hongchun Wu, Na Li, Jiachun Lu, Yifeng Zhou, Increased Levels of the Long Intergenic Non–Protein Coding RNA POU3F3 Promote DNA Methylation in Esophageal Squamous Cell Carcinoma Cells Gastroenterology. ,vol. 146, pp. 1714- 1726 ,(2014) , 10.1053/J.GASTRO.2014.03.002
Youichirou Matsuzaki, Toshiyuki Sakai, INK4 Family : A Promising Target for 'Gene-Regulating Chemoprevention' and 'Molecular-Targeting Prevention' of Cancer Environmental Health and Preventive Medicine. ,vol. 10, pp. 72- 77 ,(2005) , 10.1007/BF02897996
Chiara Pastori, Claes Wahlestedt, Involvement of long noncoding RNAs in diseases affecting the central nervous system RNA Biology. ,vol. 9, pp. 860- 870 ,(2012) , 10.4161/RNA.20482
Wai Leong Tam, Robert A Weinberg, The epigenetics of epithelial-mesenchymal plasticity in cancer. Nature Medicine. ,vol. 19, pp. 1438- 1449 ,(2013) , 10.1038/NM.3336
Sina Gogolin, Volker Ehemann, Gabriele Becker, Lena M. Brueckner, Daniel Dreidax, Steffen Bannert, Ingo Nolte, Larissa Savelyeva, Emma Bell, Frank Westermann, CDK4 inhibition restores G(1)-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage. Cell Cycle. ,vol. 12, pp. 1091- 1104 ,(2013) , 10.4161/CC.24091