Immune and regulatory functions of neutrophils in inflammatory bone loss.

摘要: Although historically viewed as merely anti-microbial effectors in acute infection or injury, neutrophils are now appreciated to be functionally versatile with critical roles also chronic inflammation. Periodontitis, a inflammatory disease that destroys the tooth-supporting gums and bone, is particularly affected by alterations neutrophil numbers function, revealed observations monogenic disorders relevant mouse models. Besides being significant debilitating health burden its own right, periodontitis thus an attractive model dissect uncharted neutrophil-associated (patho)physiological pathways. Here, we summarize recent evidence can contribute bone loss not only through typical bystander injury dogma but intriguingly their absence from tissue, where they normally perform important immunomodulatory functions. Moreover, discuss advances interactions of vascular endothelium - upon extravasation bacteria, how dysregulation these leads tissue damage. Overall, have both protective destructive periodontitis, involved maintenance periodontal homeostasis induction loss. This highlights importance developing approaches promote sustain fine balance between homeostatic immunity pathology.