Procalcitonin and New Biomarkers
作者： N. A. Mir , D. Ho , J. Toews , J. Walsham
DOI: 10.1007/978-3-319-64774-6_5
关键词: Sepsis 、 Community-acquired pneumonia 、 Biomarker (medicine) 、 Ventilator-associated pneumonia 、 Procalcitonin 、 C-reactive protein 、 Medicine 、 Immunology 、 Bacteremia 、 Pneumonia
摘要: Over the last 25 years, procalcitonin (PCT) has increasingly been utilized to identify patients with bacterial sepsis. PCT is a 14.5 kDa protein derived from CALC-1 gene and belongs family of hormones. Released liver, fat, muscle, kidney parenchymal cells, determined be quite specific infections. Although its physiology not fully elucidated, kinetics proven valuable asset clinical decision making when compared other markers inflammation such as C-reactive white cell count. also used determine commence cease antibiotic therapy across host conditions sepsis, pneumonia, burns in both adult pediatric populations. PCT’s prognostic value recognized along non-infectious indications like appendicitis burns. Relatively newer biomarkers IL-6, LBP, presepsin are being identified field critical care could provide effective strategies towards early diagnosis serious
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