Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

作者: Simon Lawton , Gerry Steele , Phil Shering , Lihua Zhao , Ian Laird

DOI: 10.1021/OP900237X

关键词: Continuous crystallizationProcess engineeringBatch processingMaterials scienceActive ingredientScientific method

摘要: In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC) …

参考文章(8)
Emilie Deneau, Gerry Steele, An In-Line Study of Oiling Out and Crystallization Organic Process Research & Development. ,vol. 9, pp. 943- 950 ,(2005) , 10.1021/OP050107C
Eva M. Ålander, Marketta S. Uusi-Penttilä, Åke C. Rasmuson, Agglomeration of Paracetamol during Crystallization in Pure and Mixed Solvents Industrial & Engineering Chemistry Research. ,vol. 43, pp. 629- 637 ,(2004) , 10.1021/IE0301280
X. Ni, P. Gough, On the discussion of the dimensionless groups governing oscillatory flow in a baffled tube Chemical Engineering Science. ,vol. 52, pp. 3209- 3212 ,(1997) , 10.1016/S0009-2509(97)00104-8
Jia Wei Chew, Pui Shan Chow, Reginald B. H. Tan, Automated In-line Technique Using FBRM to Achieve Consistent Product Quality in Cooling Crystallization Crystal Growth & Design. ,vol. 7, pp. 1416- 1422 ,(2007) , 10.1021/CG060822T
Zai Qun Yu, Pui Shan Chow, Reginald B. H. Tan, Application of attenuated total reflectance-Fourier transform infrared (ATR-FTIR) technique in the monitoring and control of anti-solvent crystallization Industrial & Engineering Chemistry Research. ,vol. 45, pp. 438- 444 ,(2006) , 10.1021/IE050660I
Michael Brunsteiner, Alan G. Jones, Federica Pratola, Sarah L. Price, Stefaan J. R. Simons, Toward a molecular understanding of crystal agglomeration Crystal Growth & Design. ,vol. 5, pp. 3- 16 ,(2005) , 10.1021/CG049837M
Gary Nichols, Stephen Byard, Mark J. Bloxham, Joanne Botterill, Neil J. Dawson, Andrew Dennis, Valerie Diart, Nigel C. North, John D. Sherwood, A Review of the Terms Agglomerate and Aggregate with a Recommendation for Nomenclature Used in Powder and Particle Characterization Journal of Pharmaceutical Sciences. ,vol. 91, pp. 2103- 2109 ,(2002) , 10.1002/JPS.10191